β-CASOMORPHIN: AN OPIOID BIOACTIVE PEPTIDE IN BOVINE MILK HAVE IMPACT ON HUMAN HEALTH

Abstract

Earlier, the research was conducted to enhance the shelf life of milk. There was not much known about the health hazardous substances in the milk found naturally. It was noticed an increased incidence in the cardiovascular diseases due to consumption of bovine milk in humans. In last decade, this opinion was changed because of research advancement regarding the bioactive peptides presence in milk. Casein is chief protein fraction in milk. Bioactive peptides are usually generated in vivo through gastrointestinal procedures from numerous proteins. Bovine A1 and A2 β-casein (β-CN) are 2 alternates differing in an AA sequence i.e.at position, the histidine substituted for proline. Gastric emptying along with transit in intestine can alter peptide presence time at a site in GI tract thus influencing absorption. There are some problems like autism, cardiovascular problems and diabetes etc. have been studied as the cause of opioids bioactive peptides in humans. However, there was not conclusive evidence for the anomalies that clearly shows its role.