EFFECT OF ALUMINIUM METAL ON THE CHEMICAL STATUS OF GLUTATHIONE (GSH) IN AQUEOUS MEDIUM

Abstract

The literature on the biological aspects of Aluminium, published since the earlier review clearly reflects the growing interest in trace elements or "micronutrients" and their distribution in animal and human tissues under environmental conditions. Since there have been a large number of studies in which Aluminium has been included among various trace elements whose distribution in numerous tissues has been followed in states of health and disease with no unusual exposure to Aluminium. Ellman’s method was used to check the time and concentration dependent effect of Aluminium-Sulphate on GSH status in aqueous medium. Aluminium-Sulphate reduced the GSH level both with time and concentration. GSH reduction is due to oxidation of reduced GSH by Aluminium-Sulphate by changing it to GSSG. Present study is in vitro condition which may present the model for in vivo condition.