CHANGES IN BLOOD GLUCOSE LEVEL, GLYCOCYLATED HEMOGLOBIN LEVEL AND LIPID PROFILE AS A RESULT OF MONO-HYPOGLYCEMIC THERAPY (GLIMEPIRIDE) IN TYPE II DIABETES MELLITUS

Abstract

The aim of the present study is to work out the best possible monotherapy therapy to achieve desired glycemic status and energy metabolism in our population as assessed by the level of fasting blood glucose, HbAIc and lipid profile of Type 2 diabetes mellitus. Participants include 24 female control subjects and 48 female diabetic patients aging between 31-70 years. Blood samples were collected from the patients on two occasions spaced by three months interval. The first blood samples were collected before the start of monotherapy of Glimepiride and the second blood sample was done after three months therapy of Glimepiride from each patient. Although no direct relation of better HbAIc level with comparatively better lipid profile has not been possible to established in our selected patients, who were well controlled diabetics, yet it can be well realized that better picture of cholesterolemia is seen in diabetic patients with comparatively lower HbA1c level. The monotherapy with Glimepiride showed good and reasonable hypoglycemic effects in the diabetic patients.